I know it is possible to have multiple anki after 2.1.6+, but idk for 2.1.22, the docs says this:
If upgrading from Anki 2.1.6+, there is no need to uninstall the previous version first. All you need to do is close Anki if it is open, and then follow the installation steps above. Your cards will be preserved when you upgrade.
If upgrading from an Anki version before 2.1.6, or switching from the standard to the alternate version or vice versa, we recommend uninstalling the old version first, which will remove Anki’s program data, but not delete your card data.
If you wish to downgrade to a previous version, please make sure you downgrade first.
Install & Upgrade - Anki Manual
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