I think “the application is not responding” is a Windows error message, so I presume you’re paraphrasing? Things you could try on a Mac:
- Starting Anki while holding down the shift key
- While Anki is closed, backing up your data folder, and then renaming prefs21.db to something else
- Changing the video driver
- Checking the console output and pasting it here
https://docs.ankiweb.net/files.html#file-locations
https://docs.ankiweb.net/platform/mac/display-issues.html
https://addon-docs.ankiweb.net/console-output.html#macos